Ontology highlight
ABSTRACT:
SUBMITTER: Chick JM
PROVIDER: S-EPMC5292866 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Chick Joel M JM Munger Steven C SC Simecek Petr P Huttlin Edward L EL Choi Kwangbom K Gatti Daniel M DM Raghupathy Narayanan N Svenson Karen L KL Churchill Gary A GA Gygi Steven P SP
Nature 20160615 7608
Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a multiplexed, mass spectrometry-based method for protein quantification with an emerging outbred mouse model containing extensive genetic variation from eight inbred founder strains. By measuring genome-wide transcript and protein expression in livers from 192 Diversity outbred mice, we ide ...[more]