Ontology highlight
ABSTRACT:
SUBMITTER: Fan X
PROVIDER: S-EPMC5295442 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Fan Xiaobo X Zhao Fengfeng F Wang Xiyong X Wu Guoqiu G
Oncotarget 20160901 36
In this study, we designed and fabricated self-assembly nanospheres, which consisted of a P45 peptide and doxorubicin (Dox). P45 is a hybrid peptide composed of an Arg-Gly-Asp motif linked to the human matrilin-1 C-terminal domain by a serine linker. The fabricated nanospheres had a uniform mulberry-like spherical shape, a diameter of 63 nm, excellent polydispersity, and high Dox drug-loading efficiency. In the presence of the RGD motif, the Dox/P45 nanospheres could specifically target A549 cel ...[more]