Spontaneous Self-Assembly of Single-Chain Amphiphilic Polymeric Nanoparticles in Water.

ABSTRACT: Single-chain polymeric nanoparticles (SCPNs) have great potential as functional nanocarriers for drug delivery and bioimaging, but synthetic challenges in terms of final yield and purification procedures limit their use. A new concept to modify and improve the synthetic procedures used to generate water-soluble SCPNs through amphiphilic interactions has been successfully exploited. We developed a new ultrahigh molecular weight amphiphilic polymer containing a hydrophobic poly(epichlorohydrin) backbone and hydrophilic poly(ethylene glycol) side chains. The polymer spontaneously self-assembles into SCPNs in aqueous solution and does not require subsequent purification. The resulting SCPNs possess a number of distinct physical properties, including a uniform hydrodynamic nanoparticle diameter

SUBMITTER: Huang SY 

PROVIDER: S-EPMC7601091 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature