Ontology highlight
ABSTRACT:
SUBMITTER: Yen M
PROVIDER: S-EPMC5296635 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Nature communications 20170201
Effective prevention strategies will be essential in reducing disease burden due to bacterial infections. Here we harness the specificity and rapid-acting properties of bacteriophages as a potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae. To this end, we test a cocktail of three virulent phages in two animal models of cholera pathogenesis (infant mouse and rabbit models). Oral administration of the phages up to 24 h before V. cholerae challenge ...[more]