Ontology highlight
ABSTRACT:
SUBMITTER: Peiris D
PROVIDER: S-EPMC5320443 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Peiris Diluka D Spector Alexander F AF Lomax-Browne Hannah H Azimi Tayebeh T Ramesh Bala B Loizidou Marilena M Welch Hazel H Dwek Miriam V MV
Scientific reports 20170222
Alterations in protein glycosylation are a key feature of oncogenesis and have been shown to affect cancer cell behaviour perturbing cell adhesion, favouring cell migration and metastasis. This study investigated the effect of N-linked glycosylation on the binding of Herceptin to HER2 protein in breast cancer and on the sensitivity of cancer cells to the chemotherapeutic agent doxorubicin (DXR) and growth factors (EGF and IGF-1). The interaction between Herceptin and recombinant HER2 protein and ...[more]