Ontology highlight
ABSTRACT:
SUBMITTER: Takayama Y
PROVIDER: S-EPMC5320485 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Takayama Yasunori Y Furue Hidemasa H Tominaga Makoto M
Scientific reports 20170222
Interactions between calcium-activated chloride channel anoctamin 1 (ANO1) and transient receptor potential vanilloid 1 (TRPV1) enhance pain sensations in mice, suggesting that ANO1 inhibition could have analgesic effects. Here we show that menthol and the menthol analogue isopropylcyclohexane (iPr-CyH) inhibited ANO1 channels in mice. The iPr-CyH derivative 4-isopropylcyclohexanol (4-iPr-CyH-OH) inhibited mouse ANO1 currents more potently than iPr-CyH. Moreover, 4-iPr-CyH-OH inhibited the activ ...[more]