Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC5323130 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Li Qiao Q Quan Lina L Lyu Jiankun J He Zenghui Z Wang Xia X Meng Jiajia J Zhao Zhenjiang Z Zhu Lili L Liu Xiaofeng X Li Honglin H
Oncotarget 20161001 40
Blocking the interaction of human programmed death 1 (hPD-1) and its ligand hPD-L1 has been a promising immunotherapy in cancer treatment. In this paper, using a computational de novo peptide design method, we designed several hPD-1 binding peptides. The most potent peptide Ar5Y_4 showed a KD value of 1.38 ± 0.39 μM, comparable to the binding affinity of the cognate hPD-L1. A Surface Plasmon Resonance (SPR) competitive binding assay result indicated that Ar5Y_4 could inhibit the interaction of h ...[more]