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Optimising Terpene Synthesis with Flow Biocatalysis.

ABSTRACT: Sesquiterpenes are an important family of natural products, many of which exhibit important pharmaceutical and agricultural properties. They are biosynthesised from farnesyl diphosphate in sesquiterpene synthase catalysed reactions. Here, we report the development of a highly efficient segmented flow system for the enzyme-catalysed continuous flow production of sesquiterpenes. Design of experiment (DoE) methods were used to optimise the performance of the flow biocatalysis, and quantitative yields were achieved by using an operationally simple but highly effective segmented flow system.

SUBMITTER: Tang X

PROVIDER: S-EPMC5324637 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Optimising Terpene Synthesis with Flow Biocatalysis.

Tang Xiaoping X Allemann Rudolf K RK Wirth Thomas T

European journal of organic chemistry 20170113 2

Sesquiterpenes are an important family of natural products, many of which exhibit important pharmaceutical and agricultural properties. They are biosynthesised from farnesyl diphosphate in sesquiterpene synthase catalysed reactions. Here, we report the development of a highly efficient segmented flow system for the enzyme-catalysed continuous flow production of sesquiterpenes. Design of experiment (DoE) methods were used to optimise the performance of the flow biocatalysis, and quantitative yiel ...[more]

PMID: 28286413

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