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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq)

ABSTRACT: We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus upon neuronal activation at 3 different time points

ORGANISM(S): Mus musculus

PROVIDER: GSE86365 | GEO | 2017/01/08

SECONDARY ACCESSION(S): PRJNA341514

REPOSITORIES: GEO

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq WT)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus upon neuronal activation at 3 different time points

2017-01-08 | GSE82010 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq KD)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus with cFos knockdown upon neuronal activation (E0 and E1)

2017-01-08 | GSE82012 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq OE)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus with cFos knockdown and overexpression upon neuronal activation (E0 and E1)

2017-01-08 | GSE82011 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus upon neuronal activation at three different time point

2017-01-08 | GSE86366 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq WT)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus upon neuronal activation at three different time point

2017-01-08 | GSE82013 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq OE)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus with cFos knockdown and/or overexpression upon neuronal activation

2017-01-08 | GSE82014 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain.

Project description:Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation using an assay for transposase-accessible chromatin using sequencing (ATAC-seq). We found genome-wide changes 1 h after activation, with enrichment of gained-open sites at active enhancer regions and at binding sites for AP1-complex components, including c-Fos. Some changes remained stable for at least 24 h. Functional analysis further implicates a critical role of c-Fos in initiating, but not maintaining, neuronal activity-induced chromatin opening. Our results reveal dynamic changes of chromatin accessibility in adult mammalian brains and suggest an epigenetic mechanism by which transient neuronal activation leads to dynamic changes in gene expression via modifying chromatin accessibility.

| S-EPMC5325677 | biostudies-literature

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-01-08 | GSE86367 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-01-08 | GSE82015 | GEO

Effect of repeated optogenetic stimulation on chromatin accessibility in the mouse dentate gyrus [ATAC-seq]

Project description:To investigate the effect of repeated neural overactivation in the chromatin accessibility of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.

2023-03-31 | GSE227201 | GEO

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