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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq KD)

ABSTRACT: We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus with cFos knockdown upon neuronal activation (E0 and E1)

ORGANISM(S): Mus musculus

PROVIDER: GSE82012 | GEO | 2017/01/08

SECONDARY ACCESSION(S): PRJNA323622

REPOSITORIES: GEO

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq OE)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus with cFos knockdown and overexpression upon neuronal activation (E0 and E1)

2017-01-08 | GSE82011 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq OE)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus with cFos knockdown and/or overexpression upon neuronal activation

2017-01-08 | GSE82014 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus upon neuronal activation at three different time point

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus upon neuronal activation at 3 different time points

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain (RNA-Seq WT)

Project description:We generated RNA profiling datasets from adult mouse dentate gyrus upon neuronal activation at three different time point

2017-01-08 | GSE82013 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain (ATAC-Seq WT)

Project description:We generated the chromatin accessibility profiling datasets from adult mouse dentate gyrus upon neuronal activation at 3 different time points

2017-01-08 | GSE82010 | GEO

Neuronal activity modifies the chromatin accessibility landscape in the adult brain.

Project description:Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation using an assay for transposase-accessible chromatin using sequencing (ATAC-seq). We found genome-wide changes 1 h after activation, with enrichment of gained-open sites at active enhancer regions and at binding sites for AP1-complex components, including c-Fos. Some changes remained stable for at least 24 h. Functional analysis further implicates a critical role of c-Fos in initiating, but not maintaining, neuronal activity-induced chromatin opening. Our results reveal dynamic changes of chromatin accessibility in adult mammalian brains and suggest an epigenetic mechanism by which transient neuronal activation leads to dynamic changes in gene expression via modifying chromatin accessibility.

| S-EPMC5325677 | biostudies-literature

Effect of repeated optogenetic stimulation on chromatin accessibility in the mouse dentate gyrus [ATAC-seq]

Project description:To investigate the effect of repeated neural overactivation in the chromatin accessibility of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.

2023-03-31 | GSE227201 | GEO

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Project description:Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although immature DGCs have hyperexcitable membrane properties in vitro, the consequences of this hyperexcitability in vivo remain unclear. In particular, the relationship between experiences that activate the dentate gyrus, such as exploration of a novel environment (NE), and downstream molecular processes that modify dentate gyrus circuitry in response to cellular activation are unknown in this cell population. We first performed quantification of immediate early gene proteins in immature (5-week-old) and mature (13-week-old) DGCs from mice exposed to a NE. Paradoxically, we observed lower immediate early gene protein expression in hyperexcitable immature DGCs. We then isolated nuclei from active and inactive immature DGCs and performed single nuclei RNA-Sequencing. Compared to mature nuclei collected from the same animal, immature DGC nuclei showed less activity-induced transcriptional change, even though they were classified as active based on expression of ARC protein. These results demonstrate that the coupling of spatial exploration, cellular activation, and transcriptional change differs between immature and mature DGCs, with blunted activity-induced changes in immature cells.

2023-02-23 | GSE214309 | GEO

Effect of repeated optogenetic stimulation on gene expression in the mouse dentate gyrus [RNA-seq]

Project description:To investigate the effect of repeated neural overactivation in the transcriptome of dentate gyrus neurons, we optogenetically stimulated mouse dentate gyrus repeatedly.

2023-03-31 | GSE227200 | GEO

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