Ontology highlight
ABSTRACT:
SUBMITTER: Datta K
PROVIDER: S-EPMC5330392 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
NMR in biomedicine 20161222 2
Hyperpolarized <sup>13</sup> C MRS allows in vivo interrogation of key metabolic pathways, with pyruvate (Pyr) the substrate of choice for current clinical studies. Knowledge of the liquid-state polarization is needed for full quantitation, and asymmetry of the C<sub>2</sub> doublet, arising from 1% naturally abundant [1,2-<sup>13</sup> C]Pyr in any hyperpolarized [1-<sup>13</sup> C]Pyr sample, has been suggested as a direct measure of in vivo C<sub>1</sub> polarization via the use of an in vitr ...[more]