Ontology highlight
ABSTRACT:
SUBMITTER: Malakar P
PROVIDER: S-EPMC5334181 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Malakar Pushkar P Shilo Asaf A Mogilevsky Adi A Stein Ilan I Pikarsky Eli E Nevo Yuval Y Benyamini Hadar H Elgavish Sharona S Zong Xinying X Prasanth Kannanganattu V KV Karni Rotem R
Cancer research 20161219 5
Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA MALAT1 is upregulated in hepatocellular carcinoma and acts as a proto-oncogene through Wnt pathway activation and induction of the oncogenic splicing factor SRSF1. Induction of SRSF1 by MALAT1 modulates SRSF1 splicing targets, enhancing the production of antiapoptotic splicing isoforms and activating the mTOR pathway by modulating the alte ...[more]