Associations of objective physical activity with insulin sensitivity and circulating adipokine profile: the Framingham Heart Study.

ABSTRACT: The purpose of this study was to explore the relation of physical activity (PA) and sedentary time (SED) to insulin sensitivity and adipokines. We assessed PA and SED using Actical accelerometers and insulin resistance (HOMA-IR) in 2109 participants (free of type 1 and 2 diabetes mellitus) from Framingham Generation 3 and Omni 2 cohorts (mean age 46?years, 54% women). Systemic inflammation (C-reactive protein [CRP]) and circulating adipokines were measured 6?years earlier. Steps per day, moderate-to-vigorous PA (MVPA) and SED per wear time (%SED) were predictor variables in multivariable regression analyses, with HOMA-IR, CRP and circulating adipokines as outcome measures. We reported that higher MVPA and more steps per day were associated with lower HOMA-IR, adjusting for %SED (??=?-0.036, P?=?0.002; ??=?-0.041, P?=?0.005). Steps were inversely associated with CRP, but were directly associated with insulin-like growth factor (IGF)-1 levels (??=?-0.111, P?=?0.002; ??=?3.293, P?=?0.007). %SED was positively associated with HOMA-IR (??=?0.033, P?

SUBMITTER: Spartano NL 

PROVIDER: S-EPMC5339058 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature