Dataset Information

An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe.

ABSTRACT: Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized ¹²⁹Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of ¹²⁹Xe gas. This device was limited by ¹²⁹Xe polarizations less than 1%, ¹²⁹Xe NMR signals smaller than 20?nT, and transport of hyperpolarized ¹²⁹Xe over millimeter lengths. Higher polarizations, versatile detection schemes, and flow of ¹²⁹Xe over larger distances are desirable for wider applications. Here we demonstrate an ultra-sensitive microfabricated platform that achieves ¹²⁹Xe polarizations reaching 7%, NMR signals exceeding 1??T, lifetimes up to 6?s, and simultaneous two-mode detection, consisting of a high-sensitivity in situ channel with signal-to-noise of 10⁵ and a lower-sensitivity ex situ detection channel which may be useful in a wider variety of conditions. ¹²⁹Xe is hyperpolarized and detected in locations more than 1?cm apart. Our versatile device is an optimal platform for microfluidic magnetic resonance in particular, but equally attractive for wider nuclear spin applications benefitting from ultra-sensitive detection, long coherences, and simple instrumentation.

SUBMITTER: Kennedy DJ

PROVIDER: S-EPMC5339783 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

An optimized microfabricated platform for the optical generation and detection of hyperpolarized <sup>129</sup>Xe.

Kennedy Daniel J DJ Seltzer Scott J SJ Jiménez-Martínez Ricardo R Ring Hattie L HL Malecek Nicolas S NS Knappe Svenja S Donley Elizabeth A EA Kitching John J Bajaj Vikram S VS Pines Alexander A

Scientific reports 20170307

Low thermal-equilibrium nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) incompatible with small-scale microfluidic devices. Hyperpolarized <sup>129</sup>Xe gas has found use in the study of many materials but has required very large and expensive instrumentation. Recently a microfabricated device with modest instrumentation demonstrated all-optical hyperpolarization and detection of <sup ...[more]

PMID: 28266629

Similar Datasets

Project description:Introduction: The ideal contrast agents for ventilation SPECT and MRI are Technegas and 129Xe gas, respectively. Despite increasing interest in the clinical utility of ventilation imaging, these modalities have not been directly compared. Therefore, our objective was to compare the ventilation defect percent (VDP) assessed by Technegas SPECT and hyperpolarized 129Xe MRI in patients scheduled to undergo lung cancer resection with and without pre-existing obstructive lung disease. Methods: Forty-one adults scheduled to undergo lung cancer resection performed same-day Technegas SPECT, hyperpolarized 129Xe MRI, spirometry, and diffusing capacity of the lung for carbon monoxide (DLCO). Ventilation abnormalities were quantified as the VDP using two different methods: adaptive thresholding (VDPT) and k-means clustering (VDPK). Correlation and agreement between VDP quantified by Technegas SPECT and 129Xe MRI were determined by Spearman correlation and Bland-Altman analysis, respectively. Results: VDP measured by Technegas SPECT and 129Xe MRI were correlated (VDPT: r = 0.48, p = 0.001; VDPK: r = 0.63, p < 0.0001). A 2.0% and 1.6% bias towards higher Technegas SPECT VDP was measured using the adaptive threshold method (VDPT: 23.0% ± 14.0% vs. 21.0% ± 5.2%, p = 0.81) and k-means method (VDPK: 9.4% ± 9.4% vs. 7.8% ± 10.0%, p = 0.02), respectively. For both modalities, higher VDP was correlated with lower FEV1/FVC (SPECT VDPT: r = -0.38, p = 0.01; MRI VDPK: r = -0.46, p = 0.002) and DLCO (SPECT VDPT: r = -0.61, p < 0.0001; MRI VDPK: r = -0.68, p < 0.0001). Subgroup analysis revealed that VDP measured by both modalities was significantly higher for participants with COPD (n = 13) than those with asthma (n = 6; SPECT VDPT: p = 0.007, MRI VDPK: p = 0.006) and those with no history of obstructive lung disease (n = 21; SPECT VDPT: p = 0.0003, MRI VDPK: p = 0.0003). Discussion: The burden of ventilation defects quantified by Technegas SPECT and 129Xe MRI VDP was correlated and greater in participants with COPD when compared to those without. Our observations indicate that, despite substantial differences between the imaging modalities, quantitative assessment of ventilation defects by Technegas SPECT and 129Xe MRI is comparable.

Dataset Information

An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe.

Publications

An optimized microfabricated platform for the optical generation and detection of hyperpolarized <sup>129</sup>Xe.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

An optimized microfabricated platform for the optical generation and detection of hyperpolarized 129Xe.

Publications

An optimized microfabricated platform for the optical generation and detection of hyperpolarized <sup>129</sup>Xe.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

An optimized microfabricated platform for the optical generation and detection of hyperpolarized ¹²⁹Xe.