Ontology highlight
ABSTRACT:
SUBMITTER: Shi H
PROVIDER: S-EPMC5339834 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Shi Hailing H Wang Xiao X Lu Zhike Z Zhao Boxuan S BS Ma Honghui H Hsu Phillip J PJ Liu Chang C He Chuan C
Cell research 20170120 3
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and tissue development. It regulates multiple steps throughout the RNA life cycle including RNA processing, translation, and decay, via the recognition by selective binding proteins. In the cytoplasm, m<sup>6</sup>A binding protein YTHDF1 facilitates translation of m<sup>6</sup>A-modified mRNAs, and YTHDF2 accelerates th ...[more]