Ontology highlight
ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC5826585 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature cell biology 20180223 3
N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m<sup>6</sup>A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m<sup>6</sup>A)C sequence. In contrast to the mRNA-de ...[more]