Unknown

Dataset Information

0

Design Rules for Membrane-Embedded Voltage-Sensing Nanoparticles.


ABSTRACT: Voltage-sensing dyes and voltage-sensing fluorescence proteins have been continually improved and as a result have provided a wealth of insights into neuronal circuits. Further improvements in voltage-sensing dyes and voltage-sensing fluorescence proteins are needed, however, for routine detection of single action potentials across a large number of individual neurons in a large field-of-view of a live mammalian brain. On the other hand, recent experiments and calculations suggest that semiconducting nanoparticles could act as efficient voltage sensors, suitable for the above-mentioned task. This study presents quantum mechanical calculations, including Auger recombination rates, of the quantum-confined Stark effect in membrane-embedded semiconducting nanoparticles, examines their possible utility as membrane voltage sensors, and provide design rules for their structure and composition.

SUBMITTER: Park K 

PROVIDER: S-EPMC5340176 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Design Rules for Membrane-Embedded Voltage-Sensing Nanoparticles.

Park Kyoungwon K   Weiss Shimon S  

Biophysical journal 20170201 4


Voltage-sensing dyes and voltage-sensing fluorescence proteins have been continually improved and as a result have provided a wealth of insights into neuronal circuits. Further improvements in voltage-sensing dyes and voltage-sensing fluorescence proteins are needed, however, for routine detection of single action potentials across a large number of individual neurons in a large field-of-view of a live mammalian brain. On the other hand, recent experiments and calculations suggest that semicondu  ...[more]

Similar Datasets

| S-EPMC2784928 | biostudies-literature
| S-EPMC8235226 | biostudies-literature
| S-EPMC6301790 | biostudies-literature
| S-EPMC3587264 | biostudies-literature
| S-EPMC5654509 | biostudies-literature
| S-EPMC5770167 | biostudies-other
| S-EPMC6479040 | biostudies-literature
| S-EPMC5862962 | biostudies-literature
| S-EPMC5940254 | biostudies-literature
| S-EPMC2247411 | biostudies-literature