Ontology highlight
ABSTRACT:
SUBMITTER: Park K
PROVIDER: S-EPMC5770167 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Park Kyoungwon K Kuo Yung Y Shvadchak Volodymyr V Ingargiola Antonino A Dai Xinghong X Hsiung Lawrence L Kim Wookyeom W Zhou Hong H Zou Peng P Levine Alex J AJ Li Jack J Weiss Shimon S
Science advances 20180112 1
We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these na ...[more]