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Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration.


ABSTRACT: We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.

SUBMITTER: Park K 

PROVIDER: S-EPMC5770167 | biostudies-other | 2018 Jan

REPOSITORIES: biostudies-other

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Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration.

Park Kyoungwon K   Kuo Yung Y   Shvadchak Volodymyr V   Ingargiola Antonino A   Dai Xinghong X   Hsiung Lawrence L   Kim Wookyeom W   Zhou Hong H   Zou Peng P   Levine Alex J AJ   Li Jack J   Weiss Shimon S  

Science advances 20180112 1


We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these na  ...[more]

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