Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.
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ABSTRACT:
SUBMITTER: Kerr JS
PROVIDER: S-EPMC5341618 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.
Kerr Jesse S JS Adriaanse Bryan A BA Greig Nigel H NH Mattson Mark P MP Cader M Zameel MZ Bohr Vilhelm A VA Fang Evandro F EF
Trends in neurosciences 20170209 3
Neurons affected in Alzheimer's disease (AD) experience mitochondrial dysfunction and a bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta peptide (Aβ) and Tau pathologies. Emerging findings suggest that the autophagy/lysosome pathway that removes damaged mitochondria (mitophagy) is also compromised in AD, resulting in the accumulation of dysfunctional mitochondria. Results in animal and cellular models of AD and in patients with sporadic late-onset AD suggest ...[more]
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