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Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review.

ABSTRACT: Alzheimer's disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer's, as they provide an in vivo window to the pathological processes occurring in Alzheimer's brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer's disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer's research and clinical practice.

SUBMITTER: Femminella GD

PROVIDER: S-EPMC6321449 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review.

Femminella Grazia Daniela GD Thayanandan Tony T Calsolaro Valeria V Komici Klara K Rengo Giuseppe G Corbi Graziamaria G Ferrara Nicola N

International journal of molecular sciences 20181122 12

Alzheimer's disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer's, as they provide an in vivo window to the pathological processes occurring in Alzheimer's brain. While some imaging tech ...[more]

PMID: 30469491

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