Ontology highlight
ABSTRACT:
SUBMITTER: Yao PJ
PROVIDER: S-EPMC5341723 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Yao Pamela J PJ Manor Uri U Petralia Ronald S RS Brose Rebecca D RD Wu Ryan T Y RT Ott Carolyn C Wang Ya-Xian YX Charnoff Ari A Lippincott-Schwartz Jennifer J Mattson Mark P MP
Molecular biology of the cell 20161208 3
Mitochondria are essential organelles whose biogenesis, structure, and function are regulated by many signaling pathways. We present evidence that, in hippocampal neurons, activation of the Sonic hedgehog (Shh) signaling pathway affects multiple aspects of mitochondria. Mitochondrial mass was increased significantly in neurons treated with Shh. Using biochemical and fluorescence imaging analyses, we show that Shh signaling activity reduces mitochondrial fission and promotes mitochondrial elongat ...[more]