Ontology highlight
ABSTRACT:
SUBMITTER: Shashar M
PROVIDER: S-EPMC5342068 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Shashar Moshe M Siwak Jamaica J Tapan Umit U Lee Shin Yin SY Meyer Rosana D RD Parrack Paige P Tan Josenia J Khatami Fatemeh F Khatami Fatemeh F Francis Jean J Zhao Qing Q Hartshorn Kevan K Kolachalama Vijaya B VB Rahimi Nader N Chitalia Vipul V
Oncotarget 20161101 44
Despite the loss of Adenomatous Polyposis Coli (APC) in a majority of colorectal cancers (CRC), not all CRCs bear hallmarks of Wnt activation, such as nuclear β-catenin. This underscores the presence of other Wnt regulators that are important to define, given the pathogenic and prognostic roles of nuclear β-catenin in human CRC. Herein, we investigated the effect of Casitas B-lineage lymphoma (c-Cbl) on nuclear β-catenin, which is an oncoprotein upregulated in CRC due to loss-of-function APC or ...[more]