Ontology highlight
ABSTRACT:
SUBMITTER: Makii C
PROVIDER: S-EPMC5342744 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Makii Chinami C Oda Katsutoshi K Ikeda Yuji Y Sone Kenbun K Hasegawa Kosei K Uehara Yuriko Y Nishijima Akira A Asada Kayo K Koso Takahiro T Fukuda Tomohiko T Inaba Kanako K Oki Shinya S Machino Hidenori H Kojima Machiko M Kashiyama Tomoko T Mori-Uchino Mayuyo M Arimoto Takahide T Wada-Hiraike Osamu O Kawana Kei K Yano Tetsu T Fujiwara Keiichi K Aburatani Hiroyuki H Osuga Yutaka Y Fujii Tomoyuki T
Oncotarget 20161101 46
MDM2, a ubiquitin ligase, suppresses wild type TP53 via proteasome-mediated degradation. We evaluated the prognostic and therapeutic value of MDM2 in ovarian clear cell carcinoma. MDM2 expression in ovarian cancer tissues was analyzed by microarray and real-time PCR, and its relationship with prognosis was evaluated by Kaplan-Meier method and log-rank test. The anti-tumor activities of MDM2 siRNA and the MDM2 inhibitor RG7112 were assessed by cell viability assay, western blotting, and flow cyto ...[more]