CCL2 nitration is a negative regulator of chemokine-mediated inflammation.
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ABSTRACT:
SUBMITTER: Barker CE
PROVIDER: S-EPMC5349559 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
CCL2 nitration is a negative regulator of chemokine-mediated inflammation.
Barker Catriona E CE Thompson Sarah S O'Boyle Graeme G Lortat-Jacob Hugues H Sheerin Neil S NS Ali Simi S Kirby John A JA
Scientific reports 20170314
Chemokines promote leukocyte recruitment during inflammation. The oxidative burst is an important effector mechanism, this leads to the generation of reactive nitrogen species (RNS), including peroxynitrite (ONOO). The current study was performed to determine the potential for nitration to alter the chemical and biological properties of the prototypical CC chemokine, CCL2. Immunofluorescence was performed to assess the presence of RNS in kidney biopsies. Co-localisation was observed between RNS- ...[more]
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