Ontology highlight
ABSTRACT:
SUBMITTER: Petersen W
PROVIDER: S-EPMC5349780 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Petersen Wiebke W Stenzel Werner W Silvie Olivier O Blanz Judith J Saftig Paul P Matuschewski Kai K Ingmundson Alyssa A
Molecular biology of the cell 20170125 6
While lysosomes are degradative compartments and one of the defenses against invading pathogens, they are also hubs of metabolic activity. Late endocytic compartments accumulate around <i>Plasmodium berghei</i> liver-stage parasites during development, and whether this is a host defense strategy or active recruitment by the parasites is unknown. In support of the latter hypothesis, we observed that the recruitment of host late endosomes (LEs) and lysosomes is reduced in <i>uis4<sup>-</sup></i> p ...[more]