Ontology highlight
ABSTRACT:
SUBMITTER: Oetjens MT
PROVIDER: S-EPMC5352965 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Oetjens Matthew T MT Bush William S WS Denny Joshua C JC Birdwell Kelly K Kodaman Nuri N Verma Anurag A Dilks Holli H HH Pendergrass Sarah A SA Ritchie Marylyn D MD Crawford Dana C DC
Pharmacogenomics 20160601 8
<h4>Aim</h4>We sought to identify potential pleiotropy involving pharmacogenes.<h4>Methods</h4>We tested 184 functional variants in 34 pharmacogenes for associations using a custom grouping of International Classification and Disease, Ninth Revision billing codes extracted from deidentified electronic health records of 6892 patients.<h4>Results</h4>We replicated several associations including ABCG2 (rs2231142) and gout (p = 1.73 × 10(-7); odds ratio [OR]: 1.73; 95% CI: 1.40-2.12); and SLCO1B1 (r ...[more]