Ontology highlight
ABSTRACT:
SUBMITTER: Ohmae S
PROVIDER: S-EPMC5353622 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Ohmae Saori S Noma Naruto N Toyomoto Masayasu M Shinohara Masahiro M Takeiri Masatoshi M Fuji Hiroaki H Takemoto Kenji K Iwaisako Keiko K Fujita Tomoko T Takeda Norihiko N Kawatani Makoto M Aoyama Mineyoshi M Hagiwara Masatoshi M Ishihama Yasushi Y Asagiri Masataka M
Scientific reports 20170316
Osteoclasts degrade bone matrix proteins via the secretion of lysosomal enzymes. However, the precise mechanisms by which lysosomal components are transported and fused to the bone-apposed plasma membrane, termed ruffled border membrane, remain elusive. Here, we identified coronin 1A as a negative regulator of exocytotic release of cathepsin K, one of the most important bone-degrading enzymes in osteoclasts. The modulation of coronin 1A expression did not alter osteoclast differentiation and ext ...[more]