Ontology highlight
ABSTRACT:
SUBMITTER: Chen P
PROVIDER: S-EPMC5355072 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chen Peng P Zheng Xiaohu X Zhou Yonggang Y Xu Yechuan Y Zhu Lixin L Qian Yeben Y
Oncotarget 20170201 8
Talin-1 is a known oncogene-associated protein. In this study, we set out to determine its role and mechanisms in hepatocellular carcinoma (HCC) progression. We found Talin-1 to be highly expressed in HCC cells relative to non-cancer liver epithelial cells and to promote tumor growth and metastasis. We used Whole Human Genome Oligo Microarray analysis with HCC cells and HCC cells in which Talin-1 was knocked down using shRNA to identify transcripts regulated by Talin-1. Of the 40,000 tested gene ...[more]