Ontology highlight
ABSTRACT:
SUBMITTER: Rao RS
PROVIDER: S-EPMC5355893 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20170307
An efficient and alternative synthetic approach has been developed to prepare various <i>N</i>-(arylethyl)piperazine-2,6-diones from 4-benzenesulfonyliminodiacetic acid and primary amines using carbonyldiimidazole in the presence of a catalytic amount of DMAP at ambient temperature. Piperazine-2,6-diones are successfully transformed to pharmaceutically useful pyridopyrazines or pyrazinoisoquinolines and ene-diamides via an imide carbonyl group activation strategy using a Brønsted acid. Subsequen ...[more]