Ontology highlight
ABSTRACT:
SUBMITTER: Edwankar RV
PROVIDER: S-EPMC3288251 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Journal of natural products 20120118 2
The development of an efficient diastereoselective method that permits rapid construction of the tetracyclic core 17 of the Strychnos-Aspidosperma alkaloids is described. Enaminone 16, synthesized in high yield, has been cyclized under the influence of a Brønsted acid to provide the core tetracyclic framework 17 of the Strychnos alkaloids in optically active form or alternatively to the β-ketoester tetrahydro-β-carboline (THBC) unit 18, by varying the equivalents of acid and the molar concentrat ...[more]