Ontology highlight
ABSTRACT:
SUBMITTER: Schutz C
PROVIDER: S-EPMC5356569 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Schütz Christian C Varela Juan Carlos JC Perica Karlo K Haupt Carl C Oelke Mathias M Schneck Jonathan P JP
Oncotarget 20161001 42
Redirection of T cells to target and destroy tumors has become an important clinical tool and major area of research in tumor immunology. Here we present a novel, nanoparticle-based approach to selectively bind antigen-specific cytotoxic T cells (CTL) and redirect them to kill tumors, termed ATR (Antigen-specific T cell Redirectors). ATR were generated by decorating nanoparticles with both an antigen-specific T cell binding moiety, either peptide loaded MHC-Ig dimer or clonotypic anti-TCR antibo ...[more]