Ontology highlight
ABSTRACT:
SUBMITTER: Cheng X
PROVIDER: S-EPMC5356833 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cheng Xin X Liu Yong-Qiang YQ Wang Gui-Zhen GZ Yang Li-Na LN Lu Yong-Zhi YZ Li Xin-Chun XC Zhou Bo B Qu Li-Wei LW Wang Xiao-Lu XL Cheng Yong-Xian YX Liu Jinsong J Tao Sheng-Ce SC Zhou Guang-Biao GB
Oncotarget 20170101 2
The S phase kinase-associated protein 1 (Skp1), an adaptor protein of the Skp1-Cul1-F-box protein complex, binds the ubiquitin E3 ligase Skp2 and is critical to its biological functions. Targeting of Skp1 by a small compound 6-O-angeloylplenolin (6-OAP) results in dissociation and degradation of Skp2 and mitotic arrest of lung cancer cells. Here, by using a proteome microarray containing 16,368 proteins and a biotinylated 6-OAP, we identified 99 proteins that could bind 6-OAP, with Skp1 and STAT ...[more]