Ontology highlight
ABSTRACT:
SUBMITTER: Grasso G
PROVIDER: S-EPMC5360464 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Grasso Giuseppe G Axelsen Paul H PH
Journal of mass spectrometry : JMS 20170101 1
When lipid membranes containing ω-6 polyunsaturated fatty acyl chains are subjected to oxidative stress, one of the reaction products is 4-hydroxy-2-nonenal (HNE)-a chemically reactive short chain alkenal that can covalently modify proteins. The ubiquitin proteasome system is involved in the clearing of proteins modified by oxidation products such as HNE, but the chemical structure, stability and function of ubiquitin may be impaired by HNE modification. To evaluate this possibility, the suscept ...[more]