Ontology highlight
ABSTRACT:
SUBMITTER: Bitra A
PROVIDER: S-EPMC5361201 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Bitra Aruna A Sistla Srinivas S Mariam Jessy J Malvi Harshada H Anand Ruchi R
Scientific reports 20170322
Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and the central portion being composed of Ras associated (RA) domain. Here, we investigate the effect of Rassf effectors on Mst1 function by mapping the interaction of various domains of Rassf1A/5 and Mst1 kinase using surface plasmon resonance (SPR). The results revealed that apart from the C-terminal SARAH domain of Mst1 whi ...[more]