Ontology highlight
ABSTRACT:
SUBMITTER: Warszycki D
PROVIDER: S-EPMC5361891 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Warszycki Dawid D Rueda Manuel M Mordalski Stefan S Kristiansen Kurt K Satała Grzegorz G Rataj Krzysztof K Chilmonczyk Zdzisław Z Sylte Ingebrigt I Abagyan Ruben R Bojarski Andrzej J AJ
Journal of chemical information and modeling 20170118 2
Despite its remarkable importance in the arena of drug design, serotonin 1A receptor (5-HT<sub>1A</sub>) has been elusive to the X-ray crystallography community. This lack of direct structural information not only hampers our knowledge regarding the binding modes of many popular ligands (including the endogenous neurotransmitter-serotonin), but also limits the search for more potent compounds. In this paper we shed new light on the 3D pharmacological properties of the 5-HT<sub>1A</sub> receptor ...[more]