Ontology highlight
ABSTRACT:
SUBMITTER: Ye M
PROVIDER: S-EPMC5362491 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ye Min M Huang Wei W Wu Wen-Wei WW Liu Yang Y Ye Sheng-Nan SN Xu Jian-Hua JH
Oncotarget 20170201 9
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy usually associated with overexpression of both epidermal growth factor receptor (EGFR) and β-catenin. FM807 is a novel curcumin analogue with antitumor activity against both poorly and well-differentiated NPC cell lines as well as good selectivity for tumor cells. FM807 actions were shown to include inhibition of cell growth, induction of necrotic/late apoptotic cell death, and G1 arrest in NPC cells. Crucially, it exhibited potent antit ...[more]