Ontology highlight
ABSTRACT:
SUBMITTER: Dibra D
PROVIDER: S-EPMC5363575 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Dibra Denada D Mitra Abhisek A Newman Melissa M Xia Xueqing X Keenan Camille C Cutrera Jeffry J JJ Mathis J Michael JM Wang Xiao-Jing XJ Myers Jeffrey J Li Shulin S
Oncotarget 20161101 47
Establishment of a permissive pre-malignant niche in concert with mutant stem are key triggers to initiate skin carcinogenesis. An understudied area of research is finding upstream regulators of both these triggers. IL27, a pleiotropic cytokine with both pro- and anti-inflammatory properties, was found to be a key regulator of both. Two step skin carcinogenesis model and K15-KRASG12D mouse model were used to understand the role of IL27 in skin tumors. CD11b-/- mice and small-molecule of ETAR sig ...[more]