Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC5363619 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Xu Chengshan C Zhang Ling L Duan Lianning L Lu Chengrong C
Oncotarget 20161101 47
Histone H2AX is a tumor suppressor protein that plays an important role in apoptosis. However, the mechanism underlying the association of H2AX with apoptosis in cancer cells remains elusive. Here, we showed that H2AX knockdown in lung cancer A549 cells affected the expression of 16 microRNAs (miRNAs), resulting in the downregulation of 1 and the upregulation of 15 miRNAs. MicroRNA-3196 (miR-3196) was identified as a target of H2AX and shown to inhibit apoptosis in lung cancer cells by targeting ...[more]