Ontology highlight
ABSTRACT:
SUBMITTER: Powers RE
PROVIDER: S-EPMC5363953 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Powers Robert E RE Gaudet Rachelle R Sotomayor Marcos M
Structure (London, England : 1993) 20170223 3
Tip links of the inner ear are protein filaments essential for hearing and balance. Two atypical cadherins, cadherin-23 and protocadherin-15, interact in a Ca<sup>2+</sup>-dependent manner to form tip links. The largely unknown structure and mechanics of these proteins are integral to understanding how tip links pull on ion channels to initiate sensory perception. Protocadherin-15 has 11 extracellular cadherin (EC) repeats. Its EC3-4 linker lacks several of the canonical Ca<sup>2+</sup>-binding ...[more]