Dataset Information

Acceleration of bone regeneration by activating Wnt/?-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.

ABSTRACT: By virtue of its excellent bioactivity and osteoconductivity, calcium phosphate cement (CPC) has been applied extensively in bone engineering. Doping a trace element into CPC can change physical characteristics and enhance osteogenesis. The trace element lithium has been demonstrated to stimulate the proliferation and differentiation of osteoblasts. We investigated the fracture-healing effect of osteoporotic defects with lithium-doped calcium phosphate cement (Li/CPC) and the underlying mechanism. Li/CPC bodies immersed in simulated body fluid converted gradually to hydroxyapatite. Li/CPC extracts stimulated the proliferation and differentiation of osteoblasts upon release of lithium ions (Li+) at 25.35?±?0.12 to 50.74?±?0.13?mg/l through activation of the Wnt/?-catenin pathway in vitro. We also examined the effect of locally administered Li+ on defects in rat tibia between CPC and Li/CPC in vivo. Micro-computed tomography and histological staining showed that Li/CPC had better osteogenesis by increasing bone mass and promoting repair in defects compared with CPC (P?

SUBMITTER: Li L

PROVIDER: S-EPMC5364554 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Acceleration of bone regeneration by activating Wnt/β-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.

Li Li L Peng Xiaozhong X Qin Yongbao Y Wang Renchong R Tang Jingli J Cui Xu X Wang Ting T Liu Wenlong W Pan Haobo H Li Bing B

Scientific reports 20170324

By virtue of its excellent bioactivity and osteoconductivity, calcium phosphate cement (CPC) has been applied extensively in bone engineering. Doping a trace element into CPC can change physical characteristics and enhance osteogenesis. The trace element lithium has been demonstrated to stimulate the proliferation and differentiation of osteoblasts. We investigated the fracture-healing effect of osteoporotic defects with lithium-doped calcium phosphate cement (Li/CPC) and the underlying mechanis ...[more]

PMID: 28338064

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Dataset Information

Acceleration of bone regeneration by activating Wnt/?-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.

Publications

Acceleration of bone regeneration by activating Wnt/β-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.

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