Ontology highlight
ABSTRACT:
SUBMITTER: Ripolin A
PROVIDER: S-EPMC5364775 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ripolin Anastasia A Quinn James J Larrañeta Eneko E Vicente-Perez Eva Maria EM Barry Johanne J Donnelly Ryan F RF
International journal of pharmaceutics 20170216 1-2
We describe, for the first time, the design, production and evaluation of large microneedle patches. Such systems, based on 16 individual microneedle arrays (needle height 600μm), were prepared from aqueous blends of 15% w/w Gantrez<sup>®</sup> S97 and 7.5% w/w poly(ethyleneglycol) 10,000Da. Ester-based crosslinking was confirmed by FTIR and mechanical strength was good. Insertion depths in a validated skin model were approximately 500μm. Ten human volunteers successfully self-inserted the micro ...[more]