Ontology highlight
ABSTRACT:
SUBMITTER: Kim DH
PROVIDER: S-EPMC5369665 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
PLoS biology 20170328 3
Here, we show that the enzymatic cofactor tetrahydrobiopterin (BH4) inhibits feeding in Drosophila. BH4 biosynthesis requires the sequential action of the conserved enzymes Punch, Purple, and Sepiapterin Reductase (Sptr). Although we observe increased feeding upon loss of Punch and Purple in the adult fat body, loss of Sptr must occur in the brain. We found Sptr expression is required in four adult neurons that express neuropeptide F (NPF), the fly homologue of the vertebrate appetite regulator ...[more]