Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC5371228 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wang Tina T Tsui Brian B Kreisberg Jason F JF Robertson Neil A NA Gross Andrew M AM Yu Michael Ku MK Carter Hannah H Brown-Borg Holly M HM Adams Peter D PD Ideker Trey T
Genome biology 20170328 1
<h4>Background</h4>Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by conditions that increase lifespan. Mice are particularly appealing organisms for studies of mammalian aging; however, epigenetic clocks have thus far been formulated only in humans.<h4>Results</h4>We first examined whether mice and humans ex ...[more]