Ontology highlight
ABSTRACT:
SUBMITTER: Chuang TW
PROVIDER: S-EPMC6428943 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chuang Tzu-Wei TW Lu Chia-Chen CC Su Chun-Hao CH Wu Pei-Yu PY Easwvaran Sarasvathi S Lee Chi-Chieh CC Kuo Hung-Che HC Hung Kuan-Yang KY Lee Kuo-Ming KM Tsai Ching-Yen CY Tarn Woan-Yuh WY
iScience 20190309
DNA repair deficiency leads to genome instability and hence human disease. Depletion of the RNA processing factor Y14/RBM8A in cultured cells or Rbm8a haplodeficiency in the developing mouse cortex results in the accumulation of DNA damage. Y14 depletion differentially affected the expression of DNA damage response (DDR) factors and induced R-loops, both of which threaten genomic stability. Immunoprecipitation coupled with mass spectrometry revealed DDR factors as potential Y14-interacting partn ...[more]