Unknown

Dataset Information

0

Profile of Tumour Necrosis Factor Alpha -308 G/A Gene Polymorphism in Psoriatic Patients in Karnataka, India.

ABSTRACT: INTRODUCTION:Tumour necrosis factor-alpha (TNF?) gene -308G/A polymorphism (rs1800629) are associated with psoriasis in several populations worldwide. Presently, there is no literature on the status of this polymorphism in the South Indian population. AIM:To determine the profile of TNF? -308G/A polymorphism among psoriatic patients. MATERIALS AND METHODS:This case-control study involved 74 patients with Psoriasis Vulgaris (PsV) and 74 age and gender matched healthy individuals. Patients were recruited from the Department of Dermatology of R.L. Jalappa Hospital and Research Center, Tamaka, Kolar, Karnataka, India, from March 2014 to March 2016. TNF? -308G/A polymorphism was genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. RESULTS:The frequency of TNF? -308A allele 7.4% among psoriatic and 8.8% among non-psoriatic individuals. The difference was not statistically significant (p=0.82). CONCLUSION:Our results indicate that TNF? gene -308G/A polymorphism is not a significant marker for the risk of developing PsV among South Indian (Karnataka) psoriatic patients.

SUBMITTER: Rajesh D 

PROVIDER: S-EPMC5376802 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Profile of Tumour Necrosis Factor Alpha -308 G/A Gene Polymorphism in Psoriatic Patients in Karnataka, India.

Rajesh Deepa D   Chowdappa Chaitra C   Gurumurthy Rajesh R   Kutty A V Moideen AV   Balakrishna Sharath S  

Journal of clinical and diagnostic research : JCDR 20170201 2

<h4>Introduction</h4>Tumour necrosis factor-alpha (TNFα) gene -308G/A polymorphism (rs1800629) are associated with psoriasis in several populations worldwide. Presently, there is no literature on the status of this polymorphism in the South Indian population.<h4>Aim</h4>To determine the profile of TNFα -308G/A polymorphism among psoriatic patients.<h4>Materials and methods</h4>This case-control study involved 74 patients with Psoriasis Vulgaris (PsV) and 74 age and gender matched healthy individ  ...[more]

Similar Datasets

Unknown Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk.
| S-EPMC4289255 | biostudies-literature
Unknown Tumor Necrosis Factor-α 308 G/A polymorphism and psoriasis risk: A pooled analysis in different populations.
| S-EPMC7676592 | biostudies-literature
Unknown The tumor necrosis factor α (-308 A/G) polymorphism is associated with cystic fibrosis in Mexican patients.
| S-EPMC3946307 | biostudies-literature
Unknown Tumor necrosis factor-alpha-308 gene promoter polymorphism associates with survival of cancer patients: A meta-analysis.
| S-EPMC6250438 | biostudies-literature
Unknown Association of tumor necrosis factor-α -308 G/A gene polymorphism with coronary artery diseases: An evidence-based study.
| S-EPMC6817255 | biostudies-literature
Unknown Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis.
| S-EPMC5346759 | biostudies-literature
Unknown Association of tumor necrosis factor alpha -308 single nucleotide polymorphism with SARS CoV-2 infection in an Iraqi Kurdish population.
| S-EPMC9102518 | biostudies-literature
Unknown Tumor necrosis factor-alpha -308 G>A polymorphism, adherence to Mediterranean diet, and risk of overweight/obesity in young women.
| S-EPMC4083707 | biostudies-literature
Unknown Tumor necrosis factor-α -308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis.
| S-EPMC5706923 | biostudies-literature
Unknown Tumour necrosis factor gene polymorphism and disease prevalence.
| S-EPMC7169614 | biostudies-literature