B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation: A Pilot Human Intervention Trial.

ABSTRACT: Ambient fine particle (PM_2.5) pollution triggers acute cardiovascular events. Individual-level preventions are proposed to complement regulation in reducing the global burden of PM_2.5-induced cardiovascular diseases. We determine whether B vitamin supplementation mitigates PM_2.5 effects on cardiac autonomic dysfunction and inflammation in a single-blind placebo-controlled crossover pilot trial. Ten healthy adults received two-hour controlled-exposure-experiment to sham under placebo, PM_2.5 (250 μg/m³) under placebo, and PM_2.5 (250 μg/m³) under B-vitamin supplementation (2.5 mg/d folic acid, 50 mg/d vitamin B₆, and 1 mg/d vitamin B₁₂), respectively. At pre-, post-, 24 h-post-exposure, we measu

SUBMITTER: Zhong J 

PROVIDER: S-EPMC5377246 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature