Ontology highlight
ABSTRACT:
SUBMITTER: Goswami A
PROVIDER: S-EPMC5380139 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Goswami Anwesha A Liu Xiaodong X Cai Wenlong W Wyche Thomas P TP Bugni Tim S TS Meurillon Maïa M Peyrottes Suzanne S Perigaud Christian C Nonaka Koichi K Rohr Jürgen J Van Lanen Steven G SG
FEBS letters 20170125 3
LipL and Cpr19 are nonheme, mononuclear Fe(II)-dependent, α-ketoglutarate (αKG):UMP oxygenases that catalyze the formation of CO<sub>2</sub> , succinate, phosphate, and uridine-5'-aldehyde, the last of which is a biosynthetic precursor for several nucleoside antibiotics that inhibit bacterial translocase I (MraY). To better understand the chemistry underlying this unusual oxidative dephosphorylation and establish a mechanistic framework for LipL and Cpr19, we report herein the synthesis of two b ...[more]