Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
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ABSTRACT:
SUBMITTER: Ge W
PROVIDER: S-EPMC4972389 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
Ge Wei W Wolf Alexander A Feng Tianshu T Ho Chia-Hua CH Sekirnik Rok R Zayer Adam A Granatino Nicolas N Cockman Matthew E ME Loenarz Christoph C Loik Nikita D ND Hardy Adam P AP Claridge Timothy D W TDW Hamed Refaat B RB Chowdhury Rasheduzzaman R Gong Lingzhi L Robinson Carol V CV Trudgian David C DC Jiang Miao M Mackeen Mukram M MM Mccullagh James S JS Gordiyenko Yuliya Y Thalhammer Armin A Yamamoto Atsushi A Yang Ming M Liu-Yi Phebee P Zhang Zhihong Z Schmidt-Zachmann Marion M Kessler Benedikt M BM Ratcliffe Peter J PJ Preston Gail M GM Coleman Mathew L ML Schofield Christopher J CJ
Nature chemical biology 20121028 12
The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. Thi ...[more]
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