Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC5380481 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Lu Yanxin Y Kwintkiewicz Jakub J Liu Yang Y Tech Katherine K Frady Lauren N LN Su Yu-Ting YT Bautista Wendy W Moon Seog In SI MacDonald Jeffrey J Ewend Matthew G MG Gilbert Mark R MR Yang Chunzhang C Wu Jing J
Cancer research 20170215 7
Mutations in isocitrate dehydrogenase (<i>IDH</i>) are the most prevalent genetic abnormalities in lower grade gliomas. The presence of these mutations in glioma is prognostic for better clinical outcomes with longer patient survival. In the present study, we found that defects in oxidative metabolism and 2-HG production confer chemosensitization in IDH1-mutated glioma cells. In addition, temozolomide (TMZ) treatment induced greater DNA damage and apoptotic changes in mutant glioma cells. The PA ...[more]