Ontology highlight
ABSTRACT:
SUBMITTER: Lilja J
PROVIDER: S-EPMC5386136 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Lilja Johanna J Zacharchenko Thomas T Georgiadou Maria M Jacquemet Guillaume G De Franceschi Nicola N Peuhu Emilia E Hamidi Hellyeh H Pouwels Jeroen J Martens Victoria V Nia Fatemeh Hassani FH Beifuss Malte M Boeckers Tobias T Kreienkamp Hans-Juergen HJ Barsukov Igor L IL Ivaska Johanna J
Nature cell biology 20170306 4
SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed that the SPN domain is an unexpected Ras-association domain with high affinity for GTP-bound Ras and Rap G-proteins. The role of Rap1 in integrin activation is well established but the mechanisms to antagonize it remain largely unknown. Here, we show that SHANK1 and SHANK3 act as inte ...[more]